Home > Chemical Detection > Technology > Spectrometry > Time-of-Flight Mass Spectrometry (TOF-MS)

A TOF determines mass by measuring the time it takes for an ionized molecule to travel the length of a vacuum chamber to the detector. Mass detection by TOF is more accurate than that of other mass detectors and it is capable of detection over a large range, from 50 to over 150,000 Da. TOF is commonly used with MALDI ionization but can used with most ionization techniques with incorporation of an ion trap. TOF detection can be used for primary detection or as part of a MS/MS system for the detection of compound fragments.